We used Lasso regression analysis and Cox risk regression analysis to identify five CRLs (AC005332.6, AC090114.2, LINC00857, LINC02041, and AL117382.1) that were shown to be independent prognostic variables for PAAD and correctly classified PAAD patients into two separate prognosis categories. This evidence concerns the gene LINC00857 and pancreatic adenocarcinoma.