Figure 3F shows a heat map of the connection between the five CRLs’ expression and clinicopathological characteristic parameters. The two groups showed notable differences in CRL expression. To elucidate the underlying biological pathways, we performed enrichment analysis of different cluster samples using KEGG enrichment analysis and found associations with various cancer-related pathways such as the cell cycle, bladder cancer, thyroid cancer, and base excision repair (Figure 3G). The gene discussed is IL31RA; the disease is thyroid cancer.