CXCR4 and cancer: In addition, compared with untreated tumors, tumors treated with SGT-53 showed increased mRNA expression of chemokines including Cxcl9, Cxcl10, and Cxcl12 (Figure 4B), which are associated with increased infiltration of activated T cells in various human cancers via the chemokine receptors CXCR3 and CXCR4 [16].