In one study, the antiproliferative and cytotoxic potential of Berberine against NSCLC A549 cells was exhibited through activation of the p38α MAPK signaling pathway, with subsequent induction in tumor suppressor p53 and transcription factor Forkhead homeobox type O3a (FOXO3a) protein expressions. This evidence concerns the gene TP53 and non-small cell lung carcinoma.