A different mechanism of action of Berberine was elucidated by Chen et al., whereby Berberine induces cell apoptosis and suppresses NSCLC cell proliferation and growth both in vitro and in vivo models by modulating the miR-19a/TF/MAPK signaling pathway induced by Berberine-mediated upregulation of miR-19a and downregulation of tissue factor (TF) expression [90]. This evidence concerns the gene TF and non-small cell lung carcinoma.