POLE2 and lung adenocarcinoma: Thus, as a mechanism, both in vitro and in vivo lung adenocarcinoma xenografts studies indicated Berberine-mediated downregulation of forkhead box protein M1 (FoxM1), an oncoprotein transcription factor, majorly inhibiting the POLE2 expression involved in DNA replication and affecting the overall survival of lung adenocarcinoma [92].