Further, the findings in this report also suggest an important role of 8-cetylBerberine in interfering with the initiation and progression of lung cancer, assessed from three important lung cancer–associated serum biomarkers: neuron-specific enolase (NSE), cytokeratin-19 (CYFRA 21-1), and carbohydrate antigen 125 (CA125). Here, ENO2 is linked to lung cancer.