Fu et al. showed that Berberine treatment in NSCLC cells suppressed the expression of activating enhancer-binding protein-2 (AP-2) factors AP-2a and AP-2b proteins, which subsequently diminished their binding to hTERT promoter and therefore downregulated the expression of tumor-related genes including hTERT, PI3K/Akt, and Raf/MEK/ERK hTERT [89]. This evidence concerns the gene AKT1 and neoplasm.