Thus, to understand the Berberine-induced antiangiogenic effects, Fu et al. demonstrated the potency of Berberine in preventing HIF-1α expression in A549 lung cancer cells, which thereby inhibited the HIF-1α/VEGF signaling axis, resulting in the reduction of the VEGF/PEDF ratio in lung cancer cells [89]. This evidence concerns the gene SERPINF1 and lung carcinoma.