Chen et al. used bioinformatics methods to identify ESCC methylation-driven genes and established a reliable risk prognosis model consisting of GPBAR1, OLFM4, FOXI2, and CASP10 and it provided potential biomarkers for the early treatment and prognosis evaluation of ESCC [19]. This evidence concerns the gene OLFM4 and esophageal squamous cell carcinoma.