Indeed, when the levels of Tregs were determined in patients, higher percentages of Foxp3 populations could be seen in the PBMCs, and when naïve CD4+ T cells were differentiated to Tregs even though decreased numbers of expanded Tregs could be seen in ALS patients, they secreted higher levels of IL-10 when compared to the healthy controls. The gene discussed is FOXP3; the disease is amyotrophic lateral sclerosis.