RET and Hirschsprung disease: Genetic variants or mutations in RET, ZEB2, EDNRB, SOX10, L1CAM, PHOX2B, GDNF, NRTN, EDN3, ECE1, GFRA1, NRG1 were identified in HSCR patients, imparting up to 50% of the cases [3,7,8,9].