Similar to erlotinib-treated eNOS–/–db/db and waved 2 eNOS–/–db/db mice, waved 1 mice crossed to eNOS–/–db/db mice also had marked decreases in gain of body weight, fasting blood glucose, islet macrophage infiltration, and glomerulosclerosis and preserved pancreatic insulin levels. The gene discussed is NOS3; the disease is glomerulosclerosis.