Moreover, in RA patients, the phosphorylation of SYK was enhanced in B cells, particularly in patients with high ACPA levels in serum, and could be reduced by targeting T cell costimulation with abatacept (a cytotoxic T-lymphocyte-associated protein 4 immunoglobulin fusion protein, CTLA4-Ig) [151]. The gene discussed is SYK; the disease is rheumatoid arthritis.