Finally, neither an increase in TUNEL positive cells and caspase 3/7 activities (Supplemental Figure S1) nor an induction of cell cycle regulators p21WAF1 and p16INK4 (Supplemental Figure S2) were observed in BLM-AE as compared to BLM group. The gene discussed is CDKN2A; the disease is acrodermatitis enteropathica.