The suppression of PPARα in astrocytes was suggested to impair the astroglial uptake and degradation of Aβ [75], as well as to inhibit the regulation of microglial inflammatory properties by PPARα ligands, which negatively regulates nuclear factor-kappa B and activator protein-1 pathways [126,127], thus contributing to AD onset and progression. Here, PPARA is linked to Alzheimer disease.