The data on the transplanted organotypic hippocampal clearly indicate that PPARα, but not PTEN, was downregulated after transplantation with SWE cells for both murine and human genes (p < 0.01 vs. NT or HC-SH slices, Figure 9B), reinforcing the relevance of the upregulated levels of miR-21 in governing the aberrant glial phenotypes in this AD model. The gene discussed is PPARA; the disease is Alzheimer disease.