KEGG pathway analyses on two cohorts indicated that the mainly enriched pathways included the complement and coagulation cascades, cell cycle, ECM–receptor interaction, IL-17 signaling pathway, DNA replication, arrhythmogenic right ventricular cardiomyopathy, viral protein interaction with cytokine and cytokine receptor, PI3K–Akt signaling pathway, etc. The top five enriched pathways for each cohort are shown in Figure 5G,H (p. adjust < 0.05). This evidence concerns the gene AKT1 and Arrhythmogenic right ventricular dysplasia.