TNFRSF11B and breast carcinoma: Figure 1B shows that the OPG secretion level significantly differs between CAFs, TCFs and NBFs, with the highest level observed in CAFs relative to their TCFs, while NBFs secrete the lowest level of OPG. These results confirm the immunoblotting analysis data shown in Figure 1A, and indicate that OPG is upregulated in the active breast cancer-associated fibroblasts.