CD8A and autoimmune disease: Figure 3A,D show the expression of the CD38+ marker on CD4+ and CD8+ T lymphocytes, respectively. HLA-DR is a cell surface glycoprotein encoded by the HLA-DR region of the major histocompatibility complex expressed at high levels in APCs. However, HLA-DR expression in effector T lymphocytes is described in some viral infections and autoimmune diseases as a marker of activation. We observed a reduction in the percentage of CD4+ CD38+ T lymphocytes (Figure 3A).