COVID-19 patients admitted to the ICU (Intensive Care Unit) have also shown higher levels of CD95 expression on T cells as well as sFasL in plasma, both of which are associated with higher levels of caspase activation; in addition, transcripts of pro-apoptotic members of the Bcl-2 family, Bax and Bak, are upregulated. The gene discussed is BAX; the disease is COVID-19.