TNFRSF13B and common variable immunodeficiency: Additionally, the application of genetic sequencing in recent decades has allowed for reclassification of a subset of patients previously diagnosed with CVID based on consensus criteria, but who were later found to have an identifiable monogenic cause of disease or variants in genes associated with poor B cell maturation and survival (e.g., Transmembrane Activator and CAML Interactor [TACI].