The proteins that are regulated by LPS and were previously shown to be implicated in asthma and in ASM proliferation also include the upregulation of matrix-metalloproteinase-1 (MMP-1) [51] and Abelson interactor 1 (Abi1) [52] and the downregulation of insulin-like growth factor-binding protein 2 (IGFBP-2) [53]. This evidence concerns the gene IGFBP2 and asthma.