Other authors have investigated CAR-T regs in autoimmune models: Blat et al. reported decreased severity of ulcerative colitis after infusion of carcinoembryonic antigen-specific CAR-T regs [140], whereas Tenspolde et al. reported safety and long-term in vivo persistence of insulin-specific CAR-T regs in type 1 diabetes mellitus [141]. The gene discussed is INS; the disease is type 1 diabetes mellitus.