The observation that C/EBPδ contributed to the re-expression of CDH1 suggests that C/EBPδ not only regulates tumor cell aggressiveness through altering the actin-cytoskeletal dynamics via GSN and EGFR but also through the upregulation of cell-cell adhesion molecules such as CDH1, which limits the cell’s ability to dissociate from the primary tumor [44]. The gene discussed is GSN; the disease is neoplasm.