Although the interaction of AT1R and AT2R activations are of complex nature, alterations in signal transduction pathways by Ang II are considered physiological under acute conditions for the maintenance of cardiovascular function whereas chronic changes in these mechanisms due to Ang II are associated with pathological situations for the development of cardiac hypertrophy with inflammation, oxidative stress, fibrosis and apoptosis [9,72,73]. The gene discussed is AGT; the disease is cardiac hypertrophy.