Since the vital role of endogenous antioxidant defenses in the control of Ang II-mediated redox signaling in the heart, up-regulation of antioxidant enzymes (such as haeme-oxygenase-1 and thioredoxin 2), have been demonstrated to inhibit Ang II-induced oxidative stress and cardiac hypertrophy [172,173,174]. This evidence concerns the gene AGT and cardiac hypertrophy.