Additionally, ANG II activated ERK/glycogen-synthase kinase-3 (GSK3), phosphorylated heat shock transcription factor 1 (HSF1), resulting in a protein-coding gene RNF126 (ring finger protein 126) degradation for stabilizing IGF-IIR protein expression and leading to cardiac hypertrophy [91]. The gene discussed is RNF126; the disease is cardiac hypertrophy.