Since the activation of both AT2R and Mas receptors has been shown to reduce the hypertensive and hypertrophic responses due to AT1R activation [18,30,42,43,44,45], the functional significance of AT2R and Mas receptors may lie in limiting the development of Ang II-induced cardiac hypertrophy as well as preventing the transition of physiological to pathophysiological cardiac hypertrophy. Here, AGT is linked to cardiac hypertrophy.