Indeed, immune system activation, induced by GM translocation, leads to testicular and epididymal inflammation and, also, triggers insulin resistance together with gastrointestinal hormones which, in turn, affect the secretion of sex hormones [luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (T)] and their role in the regulation of spermatogenesis [89]. The gene discussed is PLOD1; the disease is Insulin resistance.