This condition determines: (i) the activation of specialized receptors known as pattern recognition receptors which serve as MAMP sensors that recognize the essential microbial components and trigger an immune response; (ii) Langerhans islet inflammation; and (iii) gastrointestinal hormonal changes with insulin resistance and the alteration of LH, FSH, and free T levels [89]. The gene discussed is BRD2; the disease is Insulin resistance.