Based on random forest permutation importance, the major predictors of COVID-19 hospitalization were aspartate transaminase (0.1451), diabetes mellitus (0.0248), chronic liver disease (0.0169), alanine transaminase (0.0110), diarrhea (0.0068), age (0.0139), and bloating (0.0011). This evidence concerns the gene GPT and COVID-19.