Mateos et al. [20] searched for all exome alterations with the lower threshold of MAF of 5%, including copy number variation and representative KRAS, GNAS, RNF43 and TP53 SNVs and INDELs with pancreatic juice cfDNA in various IPMN. This evidence concerns the gene RNF43 and pancreatic intraductal papillary-mucinous neoplasm.