Mateos et al. [20] searched for all exome alterations with the lower threshold of MAF of 5%, including copy number variation and representative KRAS, GNAS, RNF43 and TP53 SNVs and INDELs with pancreatic juice cfDNA in various IPMN. Here, KRAS is linked to pancreatic intraductal papillary-mucinous neoplasm.