PR3-ANCA positivity was significantly more prevalent in PSC patients with concurrent IBD (OR = 1.9, 95% CI: = 1.1 to 3.6; p = 0.027), especially in those with UC (OR = 2.3, 95% CI: = 1.3 to 4.1; p = 0.003) (Table 3). The gene discussed is PRTN3; the disease is inflammatory bowel disease.