A total of 10% of somatotropinomas might co-secrete prolactin; thus, DAs, meaning cabergoline and bromocriptine, represent a useful second line of medical therapy (after SSAs) or even as a first option for medical treatment in cases with a mild elevation of IGF1 that do not require SSAs (for instance, mild residual disease after pituitary surgery was already performed) [115,116]. This evidence concerns the gene IGF1 and growth hormone-producing pituitary gland neoplasm.