Alternatively, the use of clomiphene citrate, a selective estrogen receptor modulator (SERM), stimulates LH and FSH (Follicle Stimulating Hormone) with good results on fertility rates; the drug was proposed as an add-on therapy added to acromegaly accompanied by hypogonadism which is not controlled by SSAs and/or DAs [59,60,61]. Here, PLOD1 is linked to acromegaly.