In fact, all the major sodium transporters expressed along the nephron, including NHE3, the Na–K–2Cl cotransporter, and the thiazide-sensitive Na–Cl cotransporter, are detectible in the urine of rats by means of antipeptide antibodies, suggesting that profiling sodium transporters in urine may become a useful test tool for detecting and classifying kidney diseases [13]. Here, SLC5A4 is linked to kidney disorder.