After performing PSMA PET-CT and defining patients with high risk prostate cancer suspicious for positive pelvic lymph nodes, a radiotracer is injected prior to surgery that emit specific fluorescence or gamma-emitting tracers such as 99mTc or 111InPSMA, which are then able to be detected through direct vision or gamma-emitting probe detectors [132,133]. The gene discussed is FOLH1; the disease is Familial prostate cancer.