The proPSMA trial, a multicentre randomised two-armed clinical trial of 302 patients, directly compared conventional (CT plus Bone scan) staging to PSMA PET-CT as first line imaging in patients with high risk PCa (PSA > 20 ng/mL, ISUP3-5 or/and clinical stage T3 disease) [42]. Here, FOLH1 is linked to posterior cortical atrophy.