In contrast, the median lactate dehydrogenase level (580 IU/L vs. 413 IU/L, p = 0.020) and frequency of splenomegaly (44% vs. 17%, p = 0.045) were higher in patients with type 1-like CALR mutations than in those with type 2-like CALR mutations. This evidence concerns the gene CALR and Splenomegaly.