Sano et al. [26,41], based on a previous study that reported that protection from diet-induced obesity and insulin resistance in mice deficient in chemokine (CC motif) ligand 19 (CCL19) expression led to a deficiency of CCL19 receptor, suggested that the beneficial effects of Epicatechin could be induced, at least in part, by the noticeable suppression of CCL19 expression. The gene discussed is CCL19; the disease is obesity due to melanocortin 4 receptor deficiency.