The evidence reported by Shindo et [51] al proved that LIPUS induced an upregulation of the expression of vascular endothelial growth factor, endothelial nitric oxide synthase, phosphorylated ERK, and phosphorylated Akt in the infarcted area early after acute myocardial infarction, leading to enhanced angiogenesis. The gene discussed is NOS3; the disease is myocardial infarction.