In fact, both genotypes of Cav-1-knockout (Cav-1-KO) and endothelium-specific eNOS transgenic (eNOS-Tg) mice disclosed altered cardiovascular phenotypes, including cardiac hypertrophy in Cav-1-KO mice and hypotension in eNOS-Tg mice [30]. This evidence concerns the gene CAV1 and cardiac hypertrophy.