These findings were supported by earlier research that showed LCZ696 to have antiapoptotic capabilities against diabetic cardiomyopathy [40], arsenic trioxide-induced cardiotoxicity [53], cyclophosphamide-induced testicular toxicity [54], and human umbilical vein endothelial cells (HUVECs) induced by oxidized low-density lipoprotein (ox-LDL) [55] by upregulating the suppressed Bcl-2 expression and downregulating the elevated Bax and caspase-3. This evidence concerns the gene BAX and diabetic cardiomyopathy.