Downregulation in DLB:-RNA expression levels of pro-inflammatory genes (IL1B, CXCL8, and IKBKB)-RNA expression levels of proapoptotic genes (BID and TNFRSF1A, ubiquitin proteasome system (UPS) associated UBE3A, USP47, and PSMD4)Upregulation in DLB:-PTPRF, MIR556, and SMG9. The gene discussed is UBE3A; the disease is Lewy body dementia.