STING1 and systemic lupus erythematosus: Experimental findings indicate that SLE is driven by extracellular DNA delivered to endosomal TLRs via receptors, such as the B cell receptor, LL37, or FcγRs [156], whereas monogenic autoinflammatory diseases (e.g., Aicardi–Goutières syndrome; type I interferonopathy due to a DNase II deficiency) are driven by the abnormal accumulation of DNA in the cytosol, which is detected by the cGAS/STING pathway [161,162].