The cGAS-STING signaling induced by cfDNA also plays a pivotal role in a variety of sterile inflammatory diseases in humans (including ataxia-telangiectasia, familial amyotrophic lateral sclerosis, frontotemporal dementia, STING-associated vasculopathy with the onset of infancy, erosive inflammatory arthritis, psoriasis, Bloom syndrome, and Huntington’s disease) [138,163,164,165] and in murine experimental autoimmune encephalitis [164]. The gene discussed is STING1; the disease is ataxia telangiectasia.