REN and synovial sarcoma: We also assessed the relationship of CysLT with biomarkers of endothelial activation, inflammation, oxidative stress, renin–angiotensin–aldosterone system (RAAS) activation, and organ dysfunction in order to identify the pathophysiological processes associated with these mediators and evaluate their utility as biomarkers for the clinical management of SS patients, as well as their relevance as therapeutic targets to explore in the future.