TP53 and neoplasm: The combined treatment is effective not only in mut-p53 TS/A tumor-bearing mice, but also in the p53-null 4T1 model, in line with the previous observations that APR-246 is able to induce cytotoxic effects even when administered to p53-null or p53-knockdown cells, thanks to its ability to bind GSH and thus alter cell redox balance [58].