PDGFRB and central neurocytoma: In additional studies, we used shRNA-directed knockdown and CRISPR/Cas9-based knockout approaches in multiple human, mouse and rat cell-lines to characterize how loss of PHF14 action might affect neuronal proliferation and PDGFR expression and potentially contribute to development and growth of neurocytomas and demonstrated that Sunitinib effectively inhibited growth of a neurocytoma primary culture.