Musarin treatment downregulated the EGFR-Ras signaling pathway (Figure 1A) in colorectal cancer stem-like cells, including EGFR, p-Akt (Ser473), and cyclin D1, as well as p-EGFR-Y1173 and p-EGFR-Y1045. The gene discussed is EGFR; the disease is colorectal cancer.