Since genetic abnormalities are probably responsible for a small portion of increased YAP expression and activity in human cancer, the Hippo pathway’s tumorigenic capacity builds upon its ability to orchestrate multiple biological processes through a variety of molecular mechanisms, including direct activation of oncogenic transcriptional factors, crosstalk with other signaling pathways and inducing pro-tumorigenic changes in the tumor microenvironment [81,82]. The gene discussed is YAP1; the disease is cancer.