While these studies shed light on SPM (LXA4, AT-RvD1, and MaR1)-Nrf2 relationship in increasing antioxidative proteins within pulmonary physiology, there is still debate on the overall cardioprotective effects of Nrf2, with studies showing that mice with Nrf2−/−developed less atherosclerosis [58] and HMOX1 was seen highest within human plaques with characteristics of high instability [59]. Here, HMOX1 is linked to atherosclerosis.