They also revealed that Ly6Clow patrolling monocytes were enhanced in the circulation, spleen, and glomeruli of NZBWF1 mice and displayed an overexpression of genes linked with lupus pathogenesis, such as TLR7, IL-10, CD115, CD31, and TNFSF15. The gene discussed is TLR7; the disease is systemic lupus erythematosus.