IFNA1 and systemic lupus erythematosus: In addition to this, it has also been reported that IFN-α and several other proinflammatory cytokines are able to induce LMP-1 expression in B cells infected with EBV thus supporting the notion that EBV and its products are involved in key pathways modulating SLE activity and severity and may exacerbate the autoimmune phenotype observed via promoting IFN production through PRR pathways [121].