IFNA1 and systemic lupus erythematosus: A recent study by Kyogoku et al. [128] revealed that monocytes from SLE patients demonstrated a pathogenic IFN signature (activation of IRFs, GTPases, and kinases) [102] observed in autoimmune conditions augmented by the expression of cytokines, such as IL-9, IL-10, and IL-15 and mediated by the JAK/STAT signaling pathway.