In addition, several reports have revealed the molecular similarity between the EBV nuclear antigen-1 (EBNA-1) and the common lupus autoantigen Ro, as well as the inability of CD8+ T cells to control EBV-infected B cells suggesting that viruses may influence the development of SLE pathogenesis [78,79,80,81,82]. This evidence concerns the gene CALR and systemic lupus erythematosus.