In HIV infection, ROS-mediated stabilization of hypoxia-inducible factor 1α (HIF-1α) results in enriched expression of GLUT1 and C-X-C chemokine receptor type 4 (CXCR4) and in CD4+ T cells, which thereby increases glucose uptake and viral entry [108,109,110]. Here, CD4 is linked to HIV infectious disease.