The EtOH-fed+DNLA group displayed more activation of PPARα and PXR/RXRα than the EtOH-fed group, suppressed the upregulation of hepatic fibrosis signaling and death receptor signaling, and prevented the downregulation of the antioxidant action of vitamin C in the EtOH-fed group. Here, RXRA is linked to Hepatic fibrosis.