An increase in NF-kB expression was verified in both experimental groups with endometriosis, E and ME [F (1.25) = 7.23 p = 0.01]; no differences were observed between M and S groups (p > 0.99), neither between ME and E groups (p > 0.99), supporting the absence of metformin effect. Here, NFKB1 is linked to endometriosis.