EZH2 and Miyoshi myopathy: MMSET/NSD2 is an oncoprotein that is aberrantly expressed in MM that leads to abnormally high levels of H3K36 dimethylation and affects the zeste homolog 2 (EZH2) enhancers; this protein significantly decreases H3K27me3 methylation and promotes malignant cell growth, adhesion, and chromatin accessibility [75,76].