Although it has been reported that the expression of several sPLA2 isoforms (i.e., hGIB, hGIIA, hGIIE, hGIIF, hGV, hGX, hGXIIA) is increased in neoplastic tissues, two major sPLAs isoforms—namely, hGIIA and hGX—are particularly involved in a broad variety of cancer types [12,13,68,70,71]. This evidence concerns the gene PLA2G2A and cancer.