In contrast to tetanus toxin, the expression of caspase-3 eliminates PVIs in the DG, while the schizophrenia-like phenotypes cannot be attenuated by isoflurane (Figure 5), suggesting that in the absence of GABAergic transmission, PVIs presentation in the DG is required for isoflurane therapeutic effects. The gene discussed is CASP3; the disease is schizophrenia.