Here we have assessed the expression of various HSP families, including cytosolic (HSP90α, HSP90β, HSP70, HSC70, and HSP40/DNAJB1), endoplasmic reticulum (GRP78), and mitochondrial (HSP60) HSP homologs in resting and CD3/CD28-stimulated T cells in healthy controls and B-cell lymphoma patients. Here, CD28 is linked to B-cell non-Hodgkin lymphoma.