The usage of PRP treatment in vitiligo is motivated by the concentration of growth factors considered key players in melanocyte biology such as bFGF, SCF, and TGFβ (Parambath); by the broad immune system modulatory effect; and by the peculiar presence of extracellular matrix component fibrin, fibronectin, and vitronectin that serve to achieve cell adhesion between epidermal and dermal cells [196]. This evidence concerns the gene KITLG and vitiligo.