TLSs reflect the lymphoid neogenesis of organized cellular aggregates resembling secondary lymphoid organs (SLO), which occur in peripheral nonlymphoid tissues, following long- lasting exposure to inflammatory signals mediated by chemokines (i.e., CXCl13) and cytokines (i.e., Il7), generating a specific immune reaction outside SLO at the tumor site [54]. This evidence concerns the gene CXCL13 and neoplasm.