APOE and atherosclerosis: Genetically modified animal models of atherosclerosis include apolipoprotein E knockout mice (ApoE KO), low-density lipoprotein (LDL) receptor knockout mice (LDLR−/−), scavenger receptor class B member 1 knockout mice (SR-BI KO), db/db and ob/ob mice, Zucker fatty rats, and cholesterol ester transfer protein (CETP) transgenic rats [53].