It is generally accepted that Ca2+ sensitivity of myofilaments is under regulation by RhoA/Rho kinase-induced MLCP inhibition [58,59] and that dysregulation of RhoA/Rho kinase signaling results in the hypercontractile properties of VSMC, thereby contributing to the pathogenesis of hypertension [57]. The gene discussed is RHOA; the disease is hypertensive disorder.