Circulating endogenous ouabain inhibits the activity of the ouabain-sensitive Na,K-ATPase α2 subunit [4] and inhibition of the sodium pump by cardiac glycosides, such as ouabain, is associated with the pathogenesis of hypertension [17], cataract [18], and diabetic diseases [16], through the elevation of the intracellular Ca2+ concentrations. The gene discussed is ATP12A; the disease is hypertensive disorder.