PNPLA3 and fibrosis: In the multiple logistic regression model proposed to evaluate the effects of different factors on the occurrence of advanced fibrosis (Table 3), the presence of MS (OR = 13.050, p = 0.020) and AST > 32 U/I (OR = 9.039, p = 0.009) were significantly associated with the outcome, regardless of age or PNPLA3 polymorphism.