However, when this individual with borderline low level of ADAMTS13 develops sepsis due to pathogen, becomes pregnant with complication or is injured by polytrauma, ADAMTS13 insufficiency may not be able to handle the excess of ULVWF released from ECs, and can trigger the activation of ULVWF path of hemostasis and produce microthrombosis. The gene discussed is ADAMTS13; the disease is Sepsis.