Additionally, the underlying cause of vascular injury (e.g., surgery, indwelling vascular catheter), other concurrent disease (e.g., diabetes, cancer) interacting with hemostasis, environmental factor (e.g., sepsis, drug), and modifying genetic component (e.g., ADAMTS13 insufficiency, thrombophilia) are now recognized as important contributors to the complexity of thrombogenesis as detailed in Table 3. This evidence concerns the gene ADAMTS13 and Rare hereditary thrombophilia.