The second principle is “Hemostasis must be activated through ULVWF path and/or TF path”, which differentiate microthrombosis (i.e., endotheliopathy) due to activated ULVWF path in vascular wall damage limited to ECs from macrothrombosis (e.g., deep venous thrombosis) due to activated ULVWF path and activated TF path in vascular damage extending from EC to SET/EVT. This evidence concerns the gene TF and Venous thrombosis.