Illustratively, the direct effect seeable on potassium conductance in HEK293 cells, hyperkalemic conditions (18.6 mM potassium concentrations), counteracting the effect on membrane potential and depolarizations caused by hyperkalemic conditions, might annihilate L-NAME, NOS-blocker-induced aggravation, and thereby, BPC 157–hyperkalemia’s direct relationship might occur as a NO-system related interconnection. Here, NOS2 is linked to Hyperkalemia.