Commonly, endothelin relationship with NO-system dysfunction and BET-1 plasma levels might well recognize the particular BPC 157/NO-system relation and BPC 157/vascular system interplay [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41] along with its innate cytoprotection background (for review, see, i.e., [2,3,4,5,6,7,8]) on the severity of congestive heart failure [150,151,152,153,154], and the effects of therapy as well as the rate of ET-1 synthesis [143,144,152,153,154]. This evidence concerns the gene EDN1 and congestive heart failure.